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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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菌類のポリケチド合成酵素のサイクル化のステップをリダイレクトする

Suzanne M Ma1, Jixun Zhan, Xinkai Xie

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, USA.

Journal of the American Chemical Society
|December 13, 2007
PubMed
まとめ

研究者らは,チオエステラゼ/クライスンサイクラゼ (TE/CLC) ドメインを変更することで,真菌ポリケチド合成酵素 (PKS) サイクル化のステップをリダイレクトした. これにより,新しいポリケチドの合成が可能になり,真菌と細菌のPKS成分を組み合わせる可能性が示されました.

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