調

Maria L Diss1, Alan J Kennan

  • 1Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.

まとめ

研究者は,コイル・コイル二分化を制御するために新しい埋もれた極性群を設計し,安定したペプチドペアを作成しました. この画期的な発見により,単純なペプチドの混合物を用いて,異なるヘテロディメア型のコイル状コイルを形成するための直交認識が可能になった.

関連する概念動画

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¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

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Newman Projections02:06

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...