リスペリドン,ハロペリドール,およびプラセボが,知的障害のある患者の攻撃的挑戦的行動の治療における:ランダム化制御試験
Peter Tyrer1, Patricia C Oliver-Africano, Zed Ahmed
1Department of Psychological Medicine, Imperial College, London, UK. p.tyrer@imperial.ac.uk
Lancet (London, England)
|January 8, 2008
まとめ
抗精神病薬は,プラセボと比較して,知的障害のある成人の攻撃的行動を有意に改善しませんでした. これらの発見は,抗精神病薬がこの集団にとって適切な日常治療ではないことを示唆しています.
科学分野:
- 臨床心理学の臨床心理学について
- 精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,
- 知的障害の研究 知的障害の研究
背景:
- 知的障害を持つ成人の間で,攻撃的な挑戦的な行動が一般的です.
- 抗精神病薬の使用は,この行動のために頻繁に行われますが,証拠は不足しています.
- 典型的 (ハロペリドール) と非典型的 (リスペリドン) 抗精神病薬はしばしば処方されます.
研究 の 目的:
- 知的障害のある成人における攻撃的行動の治療におけるハロペリドール,リスペリドン,プラセボの有効性を比較する.
- 攻撃性,異常な行動,生活の質,悪影響の変化を評価する.
主な方法:
- 86人の非精神病の成人を対象としたランダム化比較試験で,攻撃的な挑戦的な行動が示されました.
- 参加者には,ハロペリドール,リスペリドーン,またはプラセボが割り当てられました.
- 攻撃性 (MOAS),行動,生活の質,有害影響の評価は26週間にわたって行われました.
主要な成果:
- 4週間後には,すべてのグループで攻撃性が著しく低下し,プラセボグループは最も大きな減少を示した (ベースラインから79%).
- 抗精神病薬群とプラセボ群の間で,攻撃性の減少や有害な影響における有意な差異は見つかりませんでした.
- プラセボを受けた患者は,抗精神病薬を受けた患者よりも悪い反応を示さなかった.
結論:
- 抗精神病薬は,知的障害のある個人の攻撃的な挑戦的な行動に対する通常の治療法として,証拠によって支持されていません.
- この研究は,この患者グループに抗精神病薬を処方する現在の臨床慣行に疑問を投げかけています.
- 代替的または非薬理学的介入を検討すべきである.
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