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Updated: May 5, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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欠陥のあるトリプトファンの解毒は,マウスにおける慢性粒状小胞性疾患の炎症の根底にある

Luigina Romani1, Francesca Fallarino, Antonella De Luca

  • 1Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy. lromani@unipg.it

Nature
|January 11, 2008
PubMed
まとめ

慢性粒球性疾患 (CGD) は,NADPH酸化酵素欠乏により,免疫細胞の感染と戦う能力を低下させる. この研究では,キヌレニンの経路がブロックされ,炎症を引き起こすことが明らかになり,経路の機能を回復することで逆転することができます.

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