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関連する概念動画

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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関連する実験動画

Updated: Jul 8, 2026

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

自己適応型触媒:基板に依存したリガンド構成.

Raivis Zalubovskis1, Alexis Bouet, Ester Fjellander

  • 1KTH School of Chemical Science and Engineering, Department of Chemistry, Organic Chemistry, SE 100 44 Stockholm, Sweden.

Journal of the American Chemical Society
|January 18, 2008
PubMed
まとめ
この要約は機械生成です。

柔軟なリガンドを持つパラジウム複合体は,アリル性アルキル化反応の間に,その構造を異なる基板に適応させます. この構造的適応性は,異なるアリル系で観察された様々な触媒的振る舞いを説明する.

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Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

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関連する実験動画

Last Updated: Jul 8, 2026

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

Defining Substrate Specificities for Lipase and Phospholipase Candidates
08:59

Defining Substrate Specificities for Lipase and Phospholipase Candidates

Published on: November 23, 2016

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

科学分野:

  • 有機金属化学 有機金属化学
  • カタリシス カタリシス カタリシス
  • オーガニック・シンセシス オーガニック・シンセシス

背景:

  • パラジウム触媒によるアリルアルキレーションは,有機合成における重要な反応である.
  • 触媒介質の構造を理解することは,反応結果を最適化するための鍵です.
  • リンガンド構成は,触媒反応のステレオ化学経路に大きな影響を与えます.

研究 の 目的:

  • パラジウム複合体における構成的に不安定なリガンドの構成的振る舞いを調査する.
  • パラジウム触媒によるアリルアルキル化における中間物質をモデル化するために.
  • リンガンド構造と触媒的活動と選択性を相関させるため.

主な方法:

  • 核磁共振 (NMR) スペクトロスコーピーは,核磁共振 (NMR) スペクトロスコーピーを用います.
  • 密度関数理論 (DFT) の計算
  • X線結晶グラフィーです.

主要な成果:

  • リガンドは,Pd (II) アリル複合体においてC (s) 構成を採用する.
  • リンガンドは,アリル系によって,Pd(0) オレフィン複合体において異なる構成を示す.
  • パラジウム複合体の基板への構造的適応性は,溶液状態と固体状態の両方で確認されました.
  • 観察された構造的偏好は,パラジアム触媒によるアリルアルキル化における異なるアリルアセテートの反応性と相関する.

結論:

  • コンフィギュレーションが不安定なリガンドは,重要なコンフィギュレーションの柔軟性を示しています.
  • パラジウム複合体は,様々な基板に対応するために構造を調整することができ,触媒的結果に影響を与えます.
  • この研究は,パラジアムによって触媒化されたアリルアルキレーションのメカニズムと,リガンド設計の役割についての洞察を提供します.