関連する実験動画
Updated: Jul 19, 2026

13:21
Determining heat and mechanical pain threshold in inflamed skin of human subjects
Published on: January 14, 2009
白人の男性における痛風の発生率と危険因子
R Roubenoff1, M J Klag, L A Mead
1Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md.
JAMA
|December 4, 1991
まとめ
肥満,若い成人期における著しい体重増加,高血圧は,痛風を発症させる重要な危険因子です. これらの要因の管理は,痛風の発生を予防し,それに関連する健康問題を軽減するのに役立ちます.
科学分野:
- レウマトロジーの病理学
- 予防医学は,予防的な医療です.
- エピデミオロジー エピデミオロジー
背景:
- 痛風は炎症性関節炎の一般的な形態です.
- 修正可能な危険因子を特定することは,予防戦略にとって極めて重要です.
研究 の 目的:
- 痛風の発症の潜在的に変更可能な危険因子を特定する.
主な方法:
- 縦断的なコホート研究であるジョンズ・ホプキンス・プリキュラーズ研究 (The Johns Hopkins Precursors Study) は,1271人の医学部生を追跡した.
- 収集されたデータには,医療検査とアンケートが含まれていました.
- 主なアウトカム指標は,痛風の発症であった.
主要な成果:
- 1216人の男性で60例の痛風が確認され,121人の女性で1例も発症しなかった.
- 単変数および多変数分析によって特定された重要なリスク要因には,35歳の時におけるボディマス指数,35歳までの間に過剰な体重増加,および高血圧の発生が含まれています.
- 高血圧は全体的な痛風の有意な危険因子だったが,主発痛風の有意な危険因子ではなかった.
結論:
- 肥満,若い成人期における過剰な体重増加,高血圧は,痛風の発症のリスク要因として確認されています.
- 肥満と高血圧の予防は,潜在的に痛風の発生率と罹患率を低下させる可能性があります.
- 主要および次要の痛風予防のために体重減少に関するさらなる研究が推奨されています.
関連する概念動画
Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Urinary Tract Calculi I: Introduction
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Generalized Anxiety Disorder
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...

