内皮脂酶は,ヒトの炎症によって体内において増加する
Karen O Badellino1, Megan L Wolfe, Muredach P Reilly
1School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. kbadelli@nursing.upenn.edu
Circulation
|January 24, 2008
まとめ
炎症はヒトの内皮脂酶 (EL) レベルを上昇させ,メタボリックシンドロームマーカーと相関する. この発見は,肥満における低高密度の脂質タンパク質コレステロールの説明に役立ちます.
科学分野:
- 心血管生物学 心血管生物学
- メタボリック研究
- 炎症科学 炎症科学とは
背景:
- 内皮脂酶 (EL) は,肥満および低密度高密度リポプロテインコレステロールを含む代謝症候群の特徴に関連しています.
- 肥満に関連した炎症は,ELを上調すると仮定されています.
- 以前の研究では,ELとメタボリックシンドロームの指標の間の相関が示されました.
研究 の 目的:
- 健康な個体における炎症マーカーとELレベルとの関係を調査する.
- 低用量エンドトキシンによる誘発性炎症によって血EL濃度が上昇するかどうかを検査する.
主な方法:
- 858人の被験者に炎症マーカー (hs-CRP,IL-6,TNF-RII,ICAM-1,レプチン,アディポネクチン) を測定した.
- アディポネクチンによる内皮細胞からのEL分泌を評価した.
- EL変化を測定するために20人の被験者に誘発された実験内毒性.
主要な成果:
- ELとhs-CRP,IL-6,TNF-RII,ICAM-1,およびレプチンとの間に有意な正の相関が発見されました.
- ELとアディポネクチンとの間で逆相関が観察されました.
- 実験的なエンドトキシミアにより,EL濃度が2.5倍増加し,HDLフォスホリピドの減少と相関していた.
結論:
- 血EL濃度は,ヒトの炎症マーカーと直接相関しています.
- 実験的なエンドトキシミアは,ELが炎症によって上調されていることを確認しています.
- このメカニズムは,代謝症候群と肥満における低HDLコレステロールに寄与する可能性があります.
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