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Updated: Apr 30, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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コヘシンは,CCCTC-結合因子による転写隔離を媒介する

Kerstin S Wendt1, Keisuke Yoshida, Takehiko Itoh

  • 1Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, 1030 Vienna, Austria.

Nature
|February 1, 2008
PubMed
まとめ

タンパク質複合体であるコヘシン (Cohesin) は,CTCFと働き,遺伝子発現を調節することで,転写単離体として作用する. 細胞分裂とは別に,この機能は,コルネリア・デ・ランゲ症候群のようなコヘシノパシーにおいて損なわれることがあります.

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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