左心室のダイアストリック機能不全は,収縮機能の指数として最大収縮弾性度の使用を制限する
1Department of Medicine (Cardiology), Medical University of South Carolina, Charleston 29425.
Circulation
|February 1, 1991
まとめ
最大収縮性弾性 (Emax) は,ダイアストリック機能不全がある場合,左心室 (LV) の収縮機能の低下を正確に反映しない場合があります. この研究は,心臓の健康の完全な評価のために,Emaxと並行して気圧を考慮することの重要性を強調しています.
科学分野:
- 心血管生理学 心血管の生理学
- 心臓のメカニズム 心臓のメカニズム
- 心不全に関する研究
背景:
- 左心室 (LV) の収縮機能は,心臓の出力を維持するために不可欠です.
- 最大収縮弾性 (Emax) は,LV収縮性の重要な指標である.
- 透動性機能不全は,収縮性障害と共存し,潜在的にマスクすることができます.
研究 の 目的:
- エマックスが静脈の収縮機能の低下をダイアストリック機能障害の有無で正確に検出するかどうかを調査する.
- イシュケミア・リパーフュージョンによる損傷が,正常な犬の心臓と高縮した犬の心臓において,エマックスとダイアストリック機能に与える影響を評価する.
主な方法:
- 隔離された血液を貫通した犬の心臓装置を,イソボラム LV 研究のために使用しました.
- 全身性イシュケミア (60分または90分) を通して誘発された収縮機能不全,その後再注射.
- 評価された LV 圧力,圧力-体積面積,心筋の ATP レベル,および Emax が正常な心臓および圧力の過剰負荷による心縮の心臓で評価されました.
主要な成果:
- 血性不全-再輸は,すべてのグループで開発された圧力,圧力-体積面積,ATPレベルを著しく低下させた.
- 静脈圧が保たれた正常な心臓では,エマックスは60分後に有意に減少した.
- 静脈圧が上昇した心臓 (90分不血症または補償性多動症) では,エマックスは有意に変化せず,潜在的なマスク効果を示唆した.
結論:
- Emaxは,静脈の収縮性の障害を検知することができない場合もあります.
- 高血圧の低血圧は,シストリック機能の唯一の指標としてEmaxの解釈を混乱させる可能性があります.
- 低血圧損傷後のLV機能を評価するには,ダイアストリックパラメータを含む包括的な評価が必要である.
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