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若年成人における大麻喫煙と歯周病
W Murray Thomson1, Richie Poulton, Jonathan M Broadbent
1Department of Oral Sciences, Sir John Walsh Research Institute, School of Dentistry, Dunedin, New Zealand. murray.thomson@otago.ac.nz
JAMA
|February 7, 2008
まとめ
大麻の喫煙は,タバコの使用とは独立して歯周病の危険因子です. 大麻への曝露率が高いことが,たばこ喫煙を考慮した後でも,歯周病を発症するリスクを大幅に増加させた.
科学分野:
- 口腔衛生研究 口腔衛生研究
- エピデミオロジー エピデミオロジー
- 薬物使用に関する研究 薬物使用に関する研究
背景:
- タバコの喫煙は,歯周病の既知の危険因子です.
- 歯周病への大麻喫煙の潜在的貢献は調査中です.
- 喫煙の全身的影響は,たばこと大麻の両方を口腔健康の結果と結びつけることができます.
研究 の 目的:
- 大麻の喫煙が歯周病の危険因子であるかどうかを調査する.
- 大麻使用と歯周病の発生率および重度の関連性を評価する.
主な方法:
- 1972年から1973年に生まれたニュージーランドの出生コホート (n=903) の前向きなコホート研究.
- 18,21,26,32歳のときに評価された大麻使用;26歳と32歳のときに測定された歯周病状態.
- 歯周病は,歯ごとに3箇所での結合結合喪失 (CAL) によって決定される. タバコの喫煙やその他の共変数に対する分析を制御した.
主要な成果:
- 大麻への高い曝露は,歯周病のリスクの増加と関連していました.
- 大麻への高い曝露に対する相対的なリスク:CAL ≥4mmの場合は1.6,CAL ≥5mmの場合は3.1,事故性愛着喪失の場合は2.2です.
- インシデントアタッチメント喪失は,大麻の暴露レベル (6.5%なし,11.2%ある程度,23.6%高い) により増加した.
結論:
- 大麻の喫煙は,歯周病の独立した危険因子である可能性があります.
- 研究結果は,大麻の使用が歯周病の進行に寄与することを示唆しています.
- 大麻と歯周病を結びつけるメカニズムを解明するためにさらなる研究が必要である.
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