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BRCA2変異がんにおけるシスプラチン耐性のメカニズムとしての二次変異

Wataru Sakai1, Elizabeth M Swisher, Beth Y Karlan

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

Nature
|February 12, 2008
PubMed
まとめ

BRCA2の二次変異は,BRCA2変異がんにおいてシスプラチン化学療法に対する耐性を引き起こす可能性があります. これらのBRCA2遺伝子変異は正常な機能を回復し,プラチナ製薬およびPARP阻害剤に対する耐性を引き起こす.

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