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Updated: Nov 16, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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BRCA2の内遺伝子欠損によって引き起こされる治療に対する耐性

Stacey L Edwards1, Rachel Brough, Christopher J Lord

  • 1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

Nature
|February 12, 2008
PubMed
まとめ

PARP阻害剤に対する抵抗は,BRCA2変異を有するがん細胞で発生することがあります. これは,BRCA2機能を回復し,DNA修復を可能にし,これらの薬に対する感受性を低下させる特定の削除によって起こります.

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