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関連する概念動画

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term Potentiation01:25

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Long-term Depression01:03

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Principles of Classical Conditioning01:23

Principles of Classical Conditioning

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Classical conditioning, as described by Ivan Pavlov, is a foundational concept in associative learning, where a neutral stimulus becomes capable of eliciting a conditioned response through association with an unconditioned stimulus. The process of acquisition, where this learning occurs, and the subsequent phenomena of contiguity, contingency, generalization, discrimination, extinction, and spontaneous recovery are crucial for a comprehensive understanding of classical conditioning.
During the...
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Real-World Application of Classical Conditioning01:15

Real-World Application of Classical Conditioning

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Classical conditioning not only includes the initial pairing of stimuli but also extends to more complex forms, such as higher-order conditioning. Higher-order conditioning involves creating associations beyond the primary conditioned stimulus, resulting in a chain of conditioned responses.
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
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Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
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後期コンディショニングの長期的な利益

Hélène Thibault1, Christophe Piot, Patrick Staat

  • 1Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Circulation
|February 13, 2008
PubMed
まとめ

発血後コンディショニングは,急性心筋梗塞患者の心臓発作の大きさを大幅に減らし,心臓の機能を長期的に改善します. この保護効果は,最初のイベントの数ヶ月後に持続し,回復を促進します.

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科学分野:

  • 心臓病学 心臓病学
  • 心血管研究 循環器科の研究
  • 再生医学は,再生医療である.

背景:

  • 以前に示された,発血後コンディショニングは,急性心筋梗塞 (AMI) での心臓発作の大きさのマーカーであるクレアチンキナーゼの放出を減少させます.
  • AMI患者における心臓発作のサイズと心筋機能の回復に対するポストコンディショニングの長期的な影響を調査した.

研究 の 目的:

  • 発血後コンディショニングが持続的な心臓発作のサイズ制限をもたらすかどうかを判断する.
  • 術後コンディショニングが心筋梗塞の数ヶ月後の心筋収縮機能の回復を改善するかどうかを評価する.

主な方法:

  • 皮膚経冠動脈介入を受ける最初のSTセグメント上昇心筋梗塞を有する38人の患者がランダムに割り当てられました.
  • ポストコンディショニングは,再注射後の繰り返された血管形成風船の膨張/膨張を伴う.
  • 6ヶ月で酵素放出と201タリウムSPECTによって評価された心臓発作のサイズ; 1年後にエコーカルディオグラフィによる収縮機能.

主要な成果:

  • ポストコンディショニンググループは,6ヶ月後に心筋梗塞のサイズが著しく小さかったことを示しました (11.8% vs 19.5% SPECTインデックス,P=0.04).
  • クレアチンキナーゼ (-40%) とトロポニンI (-47%) の放出が減少したのが,ポストコンディショニンググループで観察されました.
  • ポストコンディショニングされた患者は,1年後に左心房エジェクション分子が7%増加した (P=0.04).

結論:

  • 発血後コンディショニングは,AMI患者の心臓発作のサイズを継続的に減らすことができます.
  • ポストコンディショニングは,心筋収縮機能の長期的な回復を改善します.