高血圧患者におけるディピリダモールエコーカルディオグラフィーストレステスト. 目標とツール 目標とツール
A R Lucarini1, E Picano, F Lattanzi
1CNR Clinical Physiology Institute, University of Pisa, Italy.
Circulation
|May 1, 1991
まとめ
動脈高血圧は,冠動脈疾患,左心房縮,またはマイクロ血管疾患を通じて冠動脈の流れ準備に影響を及ぼします. 診断マーカーはそれぞれ異なっており,二ピリダモール検査中のエコーカルディオグラフィーとECGの変化は,異なる洞察を提供している.
科学分野:
- 心臓病学 心臓病学
- 高血圧の研究 高血圧の研究
- 診断用イメージング
背景:
- 動脈高血圧は,冠動脈疾患,左心室縮,およびマイクロ血管機能不全を含む複数の経路を通じて冠動脈のフロー・リザーブを減少させることができます.
- 効果的な診断には,これらの高血圧標的のそれぞれに合わせた明確なマーカーが必要です.
- これらのメカニズムを理解することは,高血圧患者の心血管リスク管理に不可欠です.
研究 の 目的:
- 動脈高血圧における冠動脈流量準備の減少のメカニズムの差別化における特定の診断マーカーの有用性を調査する.
- 高血圧患者におけるディピリダモール注入中の二次元エコーカルディオグラフィとエレクトロカルディオグラフィの信頼性を評価する.
主な方法:
- ディピリダモール注入中に二次元エコーカルディオグラフィを使用し,冠動脈疾患のマーカーとしての一時的な不協和性を評価しました.
- 血管学的に評価された冠動脈疾患,左心房高縮,およびマイクロ血管疾患に関連して,ダイピリダモール誘発のSTセグメントうつ病を分析した.
- 心電図の発見と心音図の評価と,ペースング中の冠動脈流量準備量測定が相関する.
主要な成果:
- エコーカルディオグラフィーの一時的な不協和性は,ノルモテンシブと高血圧の両方の患者で冠動脈疾患を確実に特定します.
- 高血圧患者におけるディピリダモール誘発のSTセグメント低血圧は,多くの場合,重大な冠動脈疾患なしに発生し,左心室縮と関連付けることができます.
- STセグメントのうつ状態は,正常な左心室質量であっても,冠動脈の流れの減少と相関し,マイクロ血管疾患を示唆する.
結論:
- エコーカルディオグラフィーは高血圧の個人に冠動脈疾患を効果的に検出します.
- 高血圧におけるディピリダモール検査中の心電図の変化は,閉塞性冠動脈疾患がない場合でも,左心室高縮または微血管疾患を示す可能性があります.
- 高血圧におけるエコー・カルディオグラフィカル・サイレント・エレクトロカルディオグラフィックの変化の臨床的意義は,早期心筋損傷のマーカーとしての役割を決定するためにさらなる調査を必要とする.
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