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関連する概念動画

The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
The Unfolded Protein Response01:37

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...

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関連する実験動画

Updated: Jul 7, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

疾患介入のためのプロテオスタシスの適応

William E Balch1, Richard I Morimoto, Andrew Dillin

  • 1Department of Cell Biology and Institute for Childhood and Neglected Diseases, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|February 16, 2008
PubMed
まとめ
この要約は機械生成です。

タンパク質ホメオスタシス (プロテオスタシス) の維持は,細胞の健康,発達,疾患の予防に不可欠です. プロテオスタシスネットワークはタンパク質の整合性を調節し,その機能不全は多くの疾患を引き起こす.

さらに関連する動画

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
06:55

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

関連する実験動画

Last Updated: Jul 7, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
06:55

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

科学分野:

  • 細胞生物学 細胞生物学
  • バイオケミストリー バイオケミストリー
  • 分子生物学は分子生物学である.

背景:

  • ユカリオット細胞は,タンパク質の完全性に対する脅威に常に直面しています.
  • タンパク質ホメオスタシス (プロテオスタシス) は,健康的な発達,老化,疾病予防に不可欠です.
  • 機能不全のプロテオスタシスは,代謝性,腫瘍性,神経変性,心血管疾患を含む様々な疾患に関連しています.

研究 の 目的:

  • プロテオスタシスネットワークと,細胞と生物の健康を維持する役割について説明する.
  • 病気の治療のためにプロテオスタシスネットワークを標的とした治療の可能性を強調する.

主な方法:

  • この研究は,プロテオスタシスネットワークの記述的概要を提供します.
  • ユカリオット細胞内のタンパク質の完全性を維持するメカニズムについて説明します.

主要な成果:

  • プロテオスタシスネットワークは,プロテオームの健康に不可欠な相互作用する活動で構成されています.
  • プロテオスタシスの欠乏は,幅広い重症疾患に起因しています.
  • プロテオスタシス調節体をターゲットにすることは,潜在的な治療戦略を提供します.

結論:

  • プロテオスタシスネットワークは,細胞と生物の健康に不可欠です.
  • プロテオスタシスの理解と操作は,困難な疾患の治療に有望である.