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関連する概念動画

Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.5K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
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Reabsorption and Secretion in the DCT and Collecting Duct01:26

Reabsorption and Secretion in the DCT and Collecting Duct

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The early phase of the DCT manages the reabsorption of approximately 10-15% of filtered water, 5–10% of filtered sodium, and 5–10% of filtered chloride. This process is facilitated by Na+–Cl− symporters in apical membranes and sodium-potassium pumps, as well as Cl− leakage channels in basolateral membranes. The early DCT also stands out as a site where parathyroid hormone (PTH) stimulates calcium reabsorption, depending on the body's requirements.
The distal...
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Testes: Histology01:27

Testes: Histology

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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
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Diphtheria01:28

Diphtheria

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Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
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Hepatitis01:25

Hepatitis

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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
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D型ヒトサイクリン

Y Xiong1, T Connolly, B Futcher

  • 1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724.

Cell
|May 17, 1991
PubMed
まとめ
この要約は機械生成です。

研究者らは,ヒトの膠原体腫細胞から新しい遺伝子であるサイクリンD1を特定した. このサイクリンD1遺伝子とそのタンパク質産物は,がん細胞系において高度に発現しているため,膠芽細胞腫の発生に潜在的役割を果たす可能性を示唆している.

さらに関連する動画

Isolation of Drosophila melanogaster Testes
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Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment
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Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

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Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
11:17

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

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Isolation of Drosophila melanogaster Testes
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Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment
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科学分野:

  • 分子生物学は分子生物学である.
  • 細胞サイクル規則 細胞サイクル規則
  • がん遺伝学 がん遺伝学

背景:

  • サイクリンは細胞循環の重要な調節体であり,A型,B型,CLN型サイクリンを含むサブクラスが知られている.
  • 非常に攻撃的な脳腫瘍であるヒトの膠芽細胞腫は,細胞循環制御の調節不全を示しています.
  • 新しい細胞循環調節体の理解は,がんのメカニズムを解読する上で極めて重要です.

研究 の 目的:

  • イーストの機能スクリーンを用いて,細胞周期調節に関与する新しい遺伝子を特定する.
  • ヒトのグリオブラストーマ細胞系から分離された,サイクリンD1と呼ばれる新発見のサイクリン遺伝子の特徴を特定する.

主な方法:

  • ヒト膠芽細胞瘤のcDNAライブラリを構築しました.
  • 特定の細胞周期変異 (CLN1とCLN2が欠け,CLN3が有条件に欠けている) を有する芽生えた酵母菌 (Saccharomyces cerevisiae) 株における機能スクリーニング.
  • トランスクリプト分析を含む,単離された遺伝子の遺伝子救済と特徴付け.

主要な成果:

  • サイクリンD1と呼ばれる新種の遺伝子が,グリオブラストームのcDNAライブラリから救出されました.
  • サイクリンD1は,既知のサイクリンとシーケンスホモロジーを示しているが,異なるサブクラスを表している.
  • サイクリンD1遺伝子は,代替ポリアデニル化によって2つの主要なトランスクリプトを生成し,トランスクリプトと34 kDaのタンパク質産物の両方が,発生した膠原生体細胞系に豊富に存在する.

結論:

  • サイクリンD1はサイクリンの新しいサブクラスである.
  • グリオブラストーマ細胞におけるサイクリンD1の高濃度は,これらのがん細胞の増殖にその潜在的な関与を示唆しています.
  • サイクリンD1の機能に関するさらなる調査は,膠原細胞腫の新たな治療標的を明らかにする可能性がある.