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Updated: Jul 7, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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フォスホイノシチドシグナル伝達は,O-GlcNAcトランスファーゼとインスリン抵抗性とのリンクを結び付けています

Xiaoyong Yang1, Pat P Ongusaha, Philip D Miles

  • 1Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature
|February 22, 2008
PubMed
まとめ

O-GlcNAcトランスファーゼ (OGT) 酵素は,インスリンに反応して細胞膜に結合し,インスリンシグナル伝達経路を変更します. このO-GlcNAcの改変は,インスリン抵抗性や2型糖尿病に寄与する.

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