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Updated: May 7, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

A PtdIns4,5P2-調節された核ポリ (A) ポリメラーゼは,選択されたmRNAの発現を制御する

David L Mellman1, Michael L Gonzales, Chunhua Song

  • 1Program in Molecular and Cellular Pharmacology, University of Wisconsin Medical School, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.

Nature
|February 22, 2008
PubMed
まとめ

核のフォスファディチリノシトール-4,5-ビスホスファート (PtdIns4,5P2) は,スター-PAPとの相互作用によって遺伝子発現を調節する. この脂質シグナル伝達分子はmRNAの3'-end形成を制御し,酸化ストレス反応遺伝子に影響を与えます.

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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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