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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

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幹細胞と初期の系統の発達

Janet Rossant1

  • 1Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Department of Molecular Genetics, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. janet.rossant@sickkids.ca

Cell
|February 26, 2008
PubMed
まとめ
この要約は機械生成です。

成人細胞を含む様々な源から派生した新しい多能幹細胞系は,異なる発達状態を呈する. これらの状態を理解することは,治療上の応用のための幹細胞の分化を導くために極めて重要です.

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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科学分野:

  • 幹細胞生物学 幹細胞生物学とは
  • 発達生物学 発達生物学とは
  • 再生医学は再生医学である.

背景:

  • 多能幹細胞系は,再プログラムされた成人体細胞を含む複数の源から派生することができます.
  • 幹細胞の微分化能力は,その発達の起源によって影響を受けます.
  • 2つの異なる多能状態,エピブラストとガストリュレントの祖先が特定されています.

研究 の 目的:

  • 様々な多能幹細胞状態の発達等価性を調査する.
  • 異なる多能性線の初期発達状態を理解する.
  • 治療用細胞の分化のための最適な開始条件を定義する.

主な方法:

  • 多能幹細胞系を様々な源から派生する.
  • 異なった多能状態の特徴.
  • 開発の可能性の比較分析.

主要な成果:

  • 多能幹細胞系は,少なくとも2つの異なる発達状態を示す.
  • これらの状態は,エピブラストの原始体と,後に胃化する胚の原始体に対応する.
  • 初期発達状態の変動は,潜在的差異化に影響する.

結論:

  • 異なる多能幹細胞状態の発達的同等性は,重要な考慮事項である.
  • 多能細胞の初期状態を理解することは,指向された分化に不可欠です.
  • この知識は,幹細胞ベースの治療法を進歩させるための鍵です.