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Updated: Jan 23, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
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単核対双核の金属結合部位:PDB調査とDFT/CDM計算から得られた金属結合親和性と選択性

Tsung-Ying Yang1, Todor Dudev, Carmay Lim

  • 1Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.

Journal of the American Chemical Society
|February 29, 2008
PubMed
まとめ

双核金属酵素には,Asp/Glu.のような一般的なブリッジリングリガンドが特徴です. 双核部位におけるMg2+は結合親和性を低下させますが,選択性を高め,望ましくない金属イオン置換から保護します.

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Conserved Binding Sites01:49

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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