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UNC93B1は,核酸を感知するトール型受容体を,エンドリゾソームに伝達する

You-Me Kim1, Melanie M Brinkmann, Marie-Eve Paquet

  • 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. ykim@wi.mit.edu

Nature
|February 29, 2008
PubMed
まとめ

タンパク質UNC-93B1は,トール型受容体 (TLRs) 7と9をエンドプラズマ網膜からエンドライソソームに輸送し,免疫反応を可能にするために不可欠です. この発見により,これらの特定のTLRの標的を絞った規制が可能になる.

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