閉経,更年期がやってきました
1Oregon Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, OR, USA. nelsonh@ohsu.edu
Lancet (London, England)
|March 4, 2008
まとめ
更年期は,卵巣ホルモンの減少のために月経の終わりを意味します. 自然な移行である一方で,熱中症と陰道乾燥だけが一貫して更年期と関連しており,治療はさまざまな結果を示しています.
科学分野:
- 生殖内分泌学 生殖内分泌学
- 女性の健康 女性の健康
- 臨床婦人科クリニック
背景:
- 更年期は,月経周期の停止によって定義される自然な生物学的プロセスです.
- 卵巣ホルモン,主にエストロゲンとプロゲステロンの分泌量の低下が特徴です.
- 症状の管理は,通常の生活イベントですが,医師の診察を受ける一般的な理由です.
研究 の 目的:
- 閉経の既知の症状をレビューする.
- 閉経症状に対する様々な治療介入の有効性と安全性を評価する.
- 更年期移行とその健康への影響を理解する知識のギャップを特定する.
主な方法:
- 更年期に関連した症状に関する疫学研究の体系的レビュー.
- 血管運動機能不全を標的とした治療法の臨床試験データの分析.
- 閉経症候群の症状治療に関連する副作用の評価.
主要な成果:
- 血管運動機能障害 (発熱) と乾燥は,流行病学的な研究で一貫して更年期と関連付けられている唯一の症状です.
- エストロゲン,ガバペンチン,パロキセチン,クロニジンを含む治療法は,血管運動機能障害に対する有効性を実証しました.
- 気分の変化や睡眠障害などの他のよく報告される症状は,更年期と二次的または無関係である可能性があります.
結論:
- 更年期は,個人に大きく異なる症状を持つ複雑な移行期である.
- 重要な更年期症状の有効な管理戦略は存在しますが,治療の有効性と副作用は慎重に検討する必要があります.
- 更年期移行とその長期的な健康への影響に関する多くの未解決の疑問に対処するために,さらなる研究が必要です.
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