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Updated: Jul 7, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

パラマグネティック・リラクゼーション・エンハンスメントを使用した溶液中の一時的な超弱タンパク質自己結合の可視化

Chun Tang1, Rodolfo Ghirlando, G Marius Clore

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.

Journal of the American Chemical Society
|March 5, 2008
PubMed
まとめ

弱いタンパク質の自己結合を検出することは困難です. この研究では,パラマグネティック・リラクゼーション・エンハンスメント (PRE) を使用して,ヒスティジンを含むタンパク質HPrの超弱相互作用を特徴付け,その自己組織化メカニズムに関する重要な詳細を明らかにしています.

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