関連する実験動画
非ポリポイド型 (平ら型およびうつ型) 結腸直腸腫瘍の流行は,無症状および症状のある成人の間にある
Roy M Soetikno1, Tonya Kaltenbach, Robert V Rouse
1Gastroenterology Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. soetikno@earthlink.net
JAMA
|March 6, 2008
まとめ
ノンポリポイド結腸直腸新生体 (NP-CRNs) は,大腸内視鏡検査中に一般的であり,ポリポイド病変よりも癌を含む可能性が高い. これらの非ポリポイド増殖の早期発見は,結腸直腸癌の予防に不可欠です.
科学分野:
- 胃腸内科 胃腸内科
- 腫瘍学 腫瘍学
- 予防医学は,予防的な医療です.
背景:
- 結腸直腸がん (CRC) は,米国における癌による死亡の主な原因である.
- 予防戦略は,主にポリポイド性腫瘍の検出と除去に焦点を当てています.
- 非ポリポイド性大腸内腫瘍 (NP-CRNs) の有意性に関するデータは限られている.
研究 の 目的:
- 退役軍人の集団におけるNP-CRNの有病率を決定する.
- NP-CRNsと結腸直腸がんの関連性を特徴づける.
主な方法:
- 選択結腸鏡検査を受けた1819人の患者の横断研究.
- エンドスコピーの外観,位置,サイズ,組織学,侵入の深さについて収集されたデータ.
- スクリーニング,監視,症状のあるサブグループにおけるNP-CRNの罹患率とがんとの関連性の分析.
主要な成果:
- NP-CRNは患者の9.35%で発見されました.
- NP-CRNsは,ポリポイド病変よりも,がん (OR,9.78) を含有する可能性が著しく高かった.
- 抑うつ型NP-CRNのリスクは最高 (33%) でした.
- 発がんのNP-CRNは,発がんのポリポイド病変よりも小さかった.
結論:
- NP-CRNsは一般的なもので,ポリポイド性腫瘍と比較して,発がんのリスクが高くなります.
- これらの発見は,大腸内視鏡検査中にNP-CRNの認識と評価の重要性を強調しています.
- 特定のリスク要因とNP-CRNの最適な管理に関するさらなる研究が必要である.
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