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ヒトの拡散型大B細胞リンパ腫における腫瘍性CARD11変異

Georg Lenz1, R Eric Davis, Vu N Ngo

  • 1Metabolism Branch, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|March 8, 2008
PubMed
まとめ

CARD11遺伝子の変異は,NF-kappaB経路を活性化することによって,分散型大B細胞リンパ腫 (DLBCL) の成長を促します. CARD11を標的にすることは,この攻撃的なB細胞がんに対する新しい治療戦略を提供します.

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