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Updated: Jul 6, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
09:37

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

タイロシンキナーゼBtkとTecは,RANKとITAMの信号をリンクすることによって,骨格細胞の分化を調節する

Masahiro Shinohara1, Takako Koga, Kazuo Okamoto

  • 1Department of Cell Signaling, Graduate School, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Cell
|March 11, 2008
PubMed
まとめ

特定のチロシンキナーゼ (BtkとTec) が欠けているマウスは,骨格細胞の機能が低下したため,オステオペトロシスを示します. この研究は,これらのキナーゼを含む重要なシグナル伝達複合体を明らかにし,骨疾患の潜在的な治療標的を提供している.

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Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

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