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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
制限的な左心室の充填パターンは,左心房圧の上昇のみによる結果ではありません
Satoshi Masutani1, William C Little, Hiroshi Hasegawa
1Cardiology Section, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1045, USA.
Circulation
|March 12, 2008
まとめ
心不全 (HF) の制限的な充填パターンは,左心房 (LA) 圧力が上昇しただけではありません. 左心室 (LV) 充填ダイナミクスの特異的な変化によって特徴付けられ,底辺の透析機能不全を示します.
科学分野:
- 心臓病学 心臓病学
- 生理学 生理学とは
背景:
- 重度の心不全 (HF) の制限的な充填パターンは,下静脈機能不全または左心房 (LA) 圧力の上昇から生じる可能性があります.
- これらの原因を区別することは,正確な診断と治療に不可欠です.
研究 の 目的:
- 左心室 (LV) の制限的な充填パターンが,高圧のLAによってのみ引き起こされるかどうかを調査する.
主な方法:
- 意識のある犬は,LA圧力,LV圧力,およびLV直径を測定する機器を装備しました.
- LV補充のダイナミクスは,同様のLA圧力上昇の2つの条件で評価されました:正常な犬の体積負荷と制限的な補充のペースで誘発されたHF.
主要な成果:
- ボリュームロードとHFの両方がピーク早期充填率 (E) を増加させた.
- しかし,HFは,体積負荷とは異なり,ピークミトラル環状速度 (E') の減少と遅延と,E減速時間の短縮を示した.
- また,HFは,LV室の硬さが増加し,緩やかなリラックスも示した.
結論:
- HFにおける制限的な充填パターンは,E'の減速と遅延と,E減速時間の短縮によって特徴付けられています.
- これらの発見は,緩やかなリラックスとLVの硬さの増加を反映し,単純なLV過填充と区別しています.
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