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Updated: May 3, 2026

Assays for the Degradation of Misfolded Proteins in Cells
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Published on: August 28, 2016

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ネイティブタンパク質複合体に対するポリグルタミン膨張の相反する効果は,SCA1に寄与する

Janghoo Lim1, Juan Crespo-Barreto, Paymaan Jafar-Nejad

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

Nature
|March 14, 2008
PubMed
まとめ

Spinocerebellar ataxia type 1 (SCA1) は,拡張されたグルタミン重複による有毒なタンパク質機能を含む. この研究は,SCA1が機能の獲得と機能の喪失の両方のメカニズムを含む,変異したタンパク質複合体の形成から生じることを示しています.

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