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Updated: Feb 11, 2026

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C型肝炎NS3/4Aプロテアゼの強力なP2-P4マクロサイクル阻害剤に対する分子モデリングベースのアプローチ

Nigel J Liverton1, M Katharine Holloway, John A McCauley

  • 1Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. nigel_liverton@merck.com

Journal of the American Chemical Society
|March 15, 2008
PubMed
まとめ

分子モデリングは,新型C型肝炎ウイルス (HCV) のNS3プロテアゼ阻害剤の設計に役立ちました. 化合物25aは,既存の臨床候補と比較して強力な活性と好ましい薬動性を示した.

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