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Updated: May 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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計算型酵素設計によるケンプ除去触媒

Daniela Röthlisberger1, Olga Khersonsky, Andrew M Wollacott

  • 1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Nature
|March 21, 2008
PubMed
まとめ

研究者らは,自然生物触媒によって以前触媒化されなかった反応を触媒化するために,新しい酵素を計算的に設計した. このタンパク質エンジニアリングの突破は,重要な速度向上を達成し,カスタム酵素を作成するための強力な新しいアプローチを示しました.

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