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Updated: Jul 6, 2026

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

Cdk1によるFOXO1の活性化が,サイクリング細胞と転移後のニューロンで起こります

Zengqiang Yuan1, Esther B E Becker, Paola Merlo

  • 1Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Science (New York, N.Y.)
|March 22, 2008
PubMed
まとめ

サイクリン依存キナーゼ1 (Cdk1) は,FOXO1転写因子をリン酸化することによって神経細胞死を引き起こす. このリン酸化は,FOXO1の核蓄積を促進し,ニューロンや増殖細胞における細胞死と遺伝子発現を促します.

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