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Updated: Jun 21, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

bcl-2はアポトーシスの複数の形態を抑制するが,チモサイトにおけるネガティブ・セレクションは抑制しない

C L Sentman1, J R Shutter, D Hockenbery

  • 1Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

Cell
|November 29, 1991
PubMed
まとめ

bcl-2タンパク質は,発達中のT細胞におけるプログラム細胞死 (アポトーシス) を防ぐ. bcl-2を未成熟のチモサイトにリダイレクトすることは,アポトーシスからそれらを保護しましたが,T細胞の選択を完全に止めることはできず,明確な死亡経路を明らかにしました.

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