フォスフォレマン媒介によるNa/K-ATPaseの活性化は,マウス室内ミオサイトにおけるβ-アドレネルジック刺激中にNa[i]とイノトロピック状態を制限する

Sanda Despa1, Amy L Tucker, Donald M Bers

  • 1Department of Physiology, Loyola University Chicago, Maywood, Ill, USA.

Circulation
|March 26, 2008
PubMed
まとめ

フォスフォレマン (PLM) リン酸化は心臓のNa/K-ATPase (NKA) を刺激し,交感活性化中に細胞内ナトリウムとカルシウム上昇を温める. これはマウスの心臓の収縮性や不律を制限する.

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