アリル炭化水素受容体によるT(reg) とT(H) 17細胞の分化制御
Francisco J Quintana1, Alexandre S Basso, Antonio H Iglesias
1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Nature
|March 26, 2008
まとめ
アリル炭化水素受容体 (AHR) は,調節性T細胞 (Treg) と炎症性T細胞 (TH17) のバランスを調節する. そのリガンド特異的な作用は,自己免疫疾患の治療のための新しい標的を提供します.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- 自己免疫疾患 自己免疫疾患
背景:
- 調節性T (Treg) 細胞とTヘルパー17 (TH17) 細胞は,相互の発達経路を持っています.
- TregとTH17細胞の調節不良は,自己免疫疾患に関与しています.
- Treg と TH17 細胞生成の生理学的調節体は,ほとんど不明のままである.
研究 の 目的:
- Treg と TH17 細胞の微分化の重要なレギュレータを特定する.
- 免疫細胞系統におけるアリル炭化水素受容体 (AHR) の役割を調査する.
- 免疫調節のための潜在的な治療標的としてAHRを探求する.
主な方法:
- アリル炭化水素受容体 (AHR) の作用をマウスモデルで調査した.
- T細胞の分化を調節するために特定のAHRリガンドを使用した.
- 実験的な自己免疫性脳内炎 (EAE) の重症度に対するAHR活性化の影響を評価した.
主要な成果:
- 2,3,7,8-テトラクロロディベンゾ-p-ダイオキシンによるAHRの活性化により,機能的なTreg細胞が促進され,EAEが抑制されました.
- 6型リンドロ[3,2-b]カルバゾールによるAHRの活性化により,Tregの発達が抑制され,TH17の分化が強化され,EAEが悪化した.
- AHRは,TregとTH17の両方の細胞の微分化のリガンド依存の調節を示しています.
結論:
- アリル炭化水素受容体 (AHR) は,TregとTH17の細胞バランスの重要な調節体です.
- AHRのリガンド特異的な活動は,自己免疫疾患における治療的免疫調節のためのユニークなメカニズムを示しています.
- AHRをターゲットにすることは,自己免疫疾患に対する新しい治療法を開発するための有望な戦略を提供します.
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