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Updated: May 5, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

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TGF-β誘発のFoxp3は,RORガマトの機能に対抗することによって,T(H) 17細胞の分化を阻害する

Liang Zhou1, Jared E Lopes, Mark M W Chong

  • 1The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA.

Nature
|March 28, 2008
PubMed
まとめ

変形成長因子β (TGF-β) 濃度は,Tヘルパー17 (T(H) 17と規制T (T(reg)) 細胞の微分を決定する. 低TGF-βはT(H) 17細胞を促進し,高TGF-βはRORガマトとFoxp3転写因子のバランスをとってT(reg) 細胞を好む.

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関連する概念動画

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General Transcription Factors01:30

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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