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Updated: Jul 6, 2026

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
06:53

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

非ヒトの霊長類におけるLNA媒介のマイクロRNAサイレンシング

Joacim Elmén1, Morten Lindow, Sylvia Schütz

  • 1Santaris Pharma, Bøge Allé 3, DK-2970 Hørsholm, Denmark.

Nature
|March 28, 2008
PubMed
まとめ

鎖核酸改変オリゴヌクレオチド (LNA-antimiRs) の全身投与は,ヒト以外の霊長類における肝臓発現マイクロRNA (miRNAs) を効果的に静止させます. このアプローチは,観察された毒性なしに血コレステロールを低下させ,治療の可能性を示しています.

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Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells07:19

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

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