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関連する概念動画

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Structure of a Gene01:30

Structure of a Gene

A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...
Eukaryotic RNA Polymerases00:58

Eukaryotic RNA Polymerases

RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
All three eukaryotic RNAPs require specific transcription factors, of which the...

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関連する実験動画

Updated: Jul 6, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

ユカリオットのゲノムはRNAマシンとして機能する.

Paulo P Amaral1, Marcel E Dinger, Tim R Mercer

  • 1Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.

Science (New York, N.Y.)
|March 29, 2008
PubMed
まとめ

ユカリオットゲノムは,遺伝子発現と細胞機能を調節する多数の非タンパク質コーディングRNA (ncRNA) を生成します. 最近の研究では,これらのncRNAがゲノム動態,細胞生物学,および発達を制御する多様な役割を明らかにしています.

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • 発達生物学 発達生物学とは

背景:

  • ユカリオットのゲノムは広く転写され,膨大な数の非タンパク質コーディングRNA (ncRNA) が生成されます.
  • ますます多くの証拠が,これらのncrRNAsの多くにとって重要な規制的役割を果たしていることを示しています.
  • ncRNAの機能を理解することは,複雑な生物学的プロセスを解読する上で極めて重要です.

研究 の 目的:

  • 非タンパク質コーディングRNA機能の理解における最近の進歩を強調する.
  • ncRNAsの多様な規制的役割を説明するために.
  • ゲノムダイナミクス,細胞生物学,発達プログラミングにおけるncRNAの関与を紹介する.

主な方法:

  • ncRNAの機能に関する最近の研究の文献レビュー.
  • ncRNA媒介調節を示す実験データの分析.
  • 異なる生物学的文脈における発見の合成.

主要な成果:

  • ユーカリオットのゲノムをcnRNAに広範囲に転写したことを示した.
  • ncRNAsによって採用される多様な規制メカニズムを特定する.

さらに関連する動画

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

関連する実験動画

Last Updated: Jul 6, 2026

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
09:30

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

Published on: September 13, 2018

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
10:19

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project

Published on: April 8, 2017

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

  • ゲノム安定性,細胞プロセス,発達経路の制御におけるncRNAの関与の例.

    • 結論:

    • 非タンパク質コーディングRNAは,真核生物における重要な調節因子である.
    • ncRNAは,ゲノムダイナミクス,細胞生物学,および発達において重要な役割を果たします.
    • ncRNAの機能に関するさらなる研究は,新しい生物学的な洞察を明らかにします.