心臓の自律的機能不全:空気中の微粒子の汚染による影響と,食中のメチル栄養素と代謝的多形性による保護
Andrea Baccarelli1, Patricia A Cassano, Augusto Litonjua
1Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA. abaccare@hsph.harvard.edu
Circulation
|April 2, 2008
まとめ
微粒子の大気汚染 (PM2.5) は,特に特定のMTHFR遺伝子変異を有する個体において,心拍数変動に悪影響を及ぼします. しかし,B6,B12,メチオニンなどのメチル栄養素の適切な摂取は,これらの有害な影響から身を守ることができます.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 心血管の健康についてです.
- 栄養科学とは,栄養科学である.
背景:
- 粒子状大気汚染 (PM2.5) は,心血管疾患の既知の危険因子です.
- PM2.5が心血管の健康に及ぼす影響のメカニズムと修正要因を理解することは極めて重要です.
研究 の 目的:
- 食事中のメチル栄養素と特定の遺伝子ポリモルフィスがPM2.5曝露と心拍数変動の関係にどのように影響するか調査する.
- 大気汚染と心血管健康の文脈で保護と感受性の要因を特定する.
主な方法:
- 549人の高齢者の心拍数変動と食事に関するデータを分析した.
- MTHFRおよびcSHMT遺伝子ポリモルフィズムに関連した心拍数変動に対するPM2.5曝露の影響の評価.
- 食中の葉酸,ビタミンB6,B12,メチオニンの変化作用の評価.
主要な成果:
- PM2.5曝露後のMTHFR [CT/TT]遺伝子型と[CC]cSHMTのキャリアにおいて,心拍数変動の低下が観察されました.
- 心拍の変動に対するPM2.5の悪影響は,ビタミンB6,B12,メチオニンの摂取量が高い個体では減少した.
- [CC] MTHFRまたは[CT/TT] cSHMTの遺伝子型を持つ被験者において,PM2.5-心拍数変動との有意な関連は見つかりませんでした.
結論:
- MTHFRおよびcSHMT遺伝子の遺伝的変異,およびメチル栄養素の食事摂取は,PM2.5.5の心血管効果を調節する上で重要な役割を果たしています.
- メチオニンの循環は,心拍数変動に対する独立した効果と,大気汚染の影響の変更の両方に関与しています.
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