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Updated: Jul 6, 2026

Transmitochondrial Cybrid Generation Using Cancer Cell Lines
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ROSを生成するミトコンドリアDNA変異は,腫瘍細胞の転移を調節することができます

Kaori Ishikawa1, Keizo Takenaga, Miho Akimoto

  • 1Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan.

Science (New York, N.Y.)
|April 5, 2008
PubMed
まとめ

癌細胞のミトコンドリアDNA (mtDNA) 変異は,癌細胞の転移能力を高めることができます. 細胞系間のmtDNAの交換により,ND6遺伝子の特定の突然変異が,呼吸と活性酸素種 (ROS) 生成に影響することで,腫瘍細胞の転移の可能性を増加させることが示されました.

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