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Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Updated: Jun 23, 2026

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
09:40

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

腫瘍発生能力を持つtRNAである.

Anton Berns1

  • 1Division of Molecular Genetics, Cancer Genomics Centre, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. a.berns@nki.nl

Cell
|April 9, 2008
PubMed
まとめ
この要約は機械生成です。

重要な転写因子であるBrf1の過剰発現は,細胞の変容と腫瘍の成長を促します. この研究は,RNAポリメラーゼIII産物,イニシアターtRNA (Met) が,これらの腫瘍発生効果に起因することを明らかにしています.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
09:40

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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科学分野:

  • 分子生物学は分子生物学である.
  • がん研究 がん研究
  • 遺伝子規制 遺伝子規制

背景:

  • Brf1はRNAポリメラーゼIIIを調節する転写因子である.
  • Brf1過剰発現は,細胞変容と腫瘍形成と関連しています.
  • Brf1が腫瘍形成を誘発する特定のメカニズムは完全に理解されていません.

研究 の 目的:

  • Brf1媒介腫瘍形成におけるRNAポリメラーゼIIIの転写産物の役割を調査する.
  • Brf1の腫瘍性作用に起因する特定の分子を特定する.
  • がん発症におけるtRNAの予期せぬ関与を解明する.

主な方法:

  • 細胞ベースのアッセイで,細胞の変容を in vitro で研究する.
  • 腫瘍形成を評価するためのインビヴォ研究.
  • RNAポリメラーゼIIIの転写産物の分析.

主要な成果:

  • マーシャル社 et al. マーシャル社 et al. Brf1の過剰発現が細胞を変容させ,腫瘍を形成することを示した.
  • 研究では,Brf1の効果の媒介者として,イニシアターtRNA (Met) を特定した.
  • この発見は,がんにおけるイニシアターtRNA (((Met)) の新たな役割を強調しています.

結論:

  • イニシエーターtRNA ((Met) はRNAポリメラーゼIIIの産物であり,Brf1誘発腫瘍発生において重要な役割を果たしている.
  • この研究は,tRNA機能とがん発症の間の予期せぬ関連性を明らかにした.
  • tRNA ((Met) をターゲティングすることで,がんに対する新たな治療戦略を提供することができる.