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関連する概念動画

RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

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関連する実験動画

Updated: Jul 5, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

テロメラーゼRNAの保存された二次構造.

D P Romero1, E H Blackburn

  • 1Department of Microbiology and Immunology, University of California, San Francisco 94143.

Cell
|October 18, 1991
PubMed
まとめ

テロメラーゼRNAとは

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • バイオケミストリー バイオケミストリー

背景:

  • テロメラーゼは,テロメアの長さを維持するために不可欠なリボ核タンパク質酵素です.
  • テロメラーゼのRNA成分は,テロメラーDNA合成のテンプレートとして機能します.
  • テロメラーゼRNAの構造を理解することは,その機能を理解するために極めて重要です.

研究 の 目的:

  • いくつかのシリアス種におけるテロメラーゼRNA (TER) の二次構造を決定する.
  • テロメアDNA合成に不可欠なTER内の保存された構造要素を特定する.
  • TER二次構造の比較的な系統遺伝モデルを構築する.

主な方法:

  • 7つのテトラヒメニンシリエートからのTER遺伝子の系統遺伝学的比較分析.
  • Tetrahymena malaccensis,T. pyriformis,T. hyperangularis,T. pigmentosa,T. hegewishii,およびGlaucoma chattoni.からのTER遺伝子のクローニングとシーケンシングを行いました.
  • 推定塩基対のコバリエーション分析による同類補完配列の識別.

主要な成果:

  • すべての分析されたテロメラーゼRNAで,プライマリ配列の急速な分岐にもかかわらず,高度に保存された二次構造が特定されました.

さらに関連する動画

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
08:26

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein

Published on: June 12, 2018

関連する実験動画

Last Updated: Jul 5, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

In vitro Reconstitution of the Active T. castaneum Telomerase

Published on: July 14, 2011

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
08:26

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein

Published on: June 12, 2018

  • テロメアテンプレート領域を取り巻く,完全に保存された22個のヌクレオチドのブロックが見つかりました.
  • コバリエーション分析により,同類の補完的な配列が明らかになり,提案された二次構造モデルを裏付けました.

    • 結論:

    • テロメラーゼRNAの二次構造は,様々なシリアス種で著しく保存されています.
    • 保存された構造,特にテンプレッティング領域は,テロメリックDNA合成におけるテロメラーゼ機能に不可欠です.
    • この研究は,テロメラーゼRNAのための堅固な二次構造モデルを提供します.