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慢性咳の流行,病原性,原因について
1Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. f.chung@imperial.ac.uk
Lancet (London, England)
|April 22, 2008
まとめ
8週間以上続く慢性咳は,喫煙,汚染,および基礎疾患などの様々な原因から生じます. 効果的な治療には,根本的な原因に対処し,咳の経路を無感化することです.
科学分野:
- 呼吸器医学とは
- クリニカルサイエンスの科学
背景:
- 咳は重要な呼吸道反射である;しかし,慢性咳 (>8週間) は,一般的なコミュニティの問題です.
- 原因は,環境要因 (喫煙,汚染) から,喘息,COPD,GERDなどの特定の疾患まで様々です.
研究 の 目的:
- 慢性咳の多因性の原因を概説する.
- 効果的な管理のために正確な診断の重要性を強調する.
- 持続的な咳の根底にある神経可塑性メカニズムを探求する.
主な方法:
- 慢性咳の一般的およびまれな原因のレビュー.
- 絶え間ない咳の診断方法についての議論.
- 神経可塑性および呼吸道炎症を含む病理生理学的メカニズムの探索.
主要な成果:
- 慢性咳は喫煙,環境汚染,喘息,COPD,GERDなどの疾患と関連しています.
- イディオパシー咳は,原因が特定されていない場合に発生します.
- 咳を誘発する物質 (咳を誘発する物質) に対する感受性の増加と,咳経路における神経可塑性変化が観察される.
結論:
- 慢性咳の効果的な管理には,根本的な疾患を特定し,治療する必要があります.
- 感受性の高い咳の経路の無敏感化は,症状制御に不可欠です.
- 構造的および炎症的呼吸道の変化は,慢性咳の原因となり,またはその結果として生じる可能性があります.
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