人間における脂肪細胞の転移の動態
Kirsty L Spalding1, Erik Arner, Pål O Westermark
1Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden. kirsty.spalding@ki.se
Nature
|May 6, 2008
まとめ
脂肪細胞 (脂肪細胞) の数は成人期に固定されますが,毎年約10%が更新されます. この一貫した脂肪細胞の周回は,肥満治療のための新しい標的を提供します.
科学分野:
- メタボリック障害 メタボリック障害
- 肥満に関する研究.
- 人間の生理学 人間の生理学
背景:
- 肥満は世界的な流行病であり,心血管疾患や2型糖尿病のリスクを高めています.
- 大人の脂肪の質量の決定因子は不明で,以前は既存の脂肪細胞の脂質貯蔵が鍵と考えられていた.
- 肥満率の上昇は,先進国の平均寿命を短縮する可能性があります.
研究 の 目的:
- 成人の脂肪の質量の決定因子としての脂肪細胞数の役割を調査する.
- 大人のアディポサイトの動態と周回率を理解するために.
- 肥満の潜在的な治療標的を特定するために.
主な方法:
- 脂肪細胞の周回数を測定するために,ゲノムDNAに14C統合の分析.
- 異なる年齢とボディマス指数における痩身と肥満の個体における脂肪細胞動態の比較.
- 早期発症肥満における脂肪細胞死亡と生成率の評価.
主要な成果:
- アディポサイト数は,成人の脂肪量の主な決定因子であり,成人期を通して一定である.
- 年齢やBMIに関係なく,成人アディポサイトの約10%が毎年更新されます.
- 脂肪細胞の転移率は厳格に規制され,早期発症の肥満では変化しません.
結論:
- 脂肪細胞数は,子供期/青春期に確立され,成人期には安定しています.
- 一貫した年間脂肪細胞更新は,安定した集団内のダイナミックなプロセスを示唆しています.
- アディポサイトの高回転は,肥満に対する薬理学的介入のための新しい治療目標です.
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