TIPE2は,先天性および適応性免疫の負の調節体であり,免疫ホメオスタシスを維持する

Honghong Sun¹, Shunyou Gong, Ruaidhri J Carmody

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell

|May 6, 2008

まとめ

腫瘍死滅因子アルファ誘発タンパク質-8型タンパク質2 (TIPE2) は,免疫ホメオスタシスにとって極めて重要です. その欠如は致命的な炎症と過敏症を引き起こし,TIPE2を強調します.

科学分野:

免疫学免疫学とは
分子生物学は分子生物学である.

背景:

免疫ホメオスタシスは,炎症性疾患の予防に不可欠です.
免疫ホメオスタシスの崩壊は,深刻な健康被害をもたらします.

研究の目的:

免疫ホメオスタシスの新しいレギュレータを特定する.
免疫調節におけるTNFAIP8ファミリーメンバーであるTIPE2の役割を調査する.

主な方法:

TIPE2機能を研究するためにマウスの遺伝子消去.
トール型受容体 (TLR) とT細胞受容体 (TCR) の活性化に対する免疫反応の分析.
TIPE2とカスパーゼ8の相互作用と下流信号伝達経路の調査.

主要な成果:

マウスにおけるTIPE2の欠失は,多臓器炎症,スプレノメガリー,早死を引き起こした.
TIPE2欠乏細胞は,TLRおよびTCR刺激に対して過敏反応を示した.
TIPE2は,カスパース-8を結合し,AP-1およびNF-kappaBの活性化を阻害し,Fas誘発のアポトーシスを促進することが判明しました.

結論:

TIPE2は,TLRとTCRの信号伝達の重要なネガティブレギュラーである.
TIPE2は,リンパ性組織の過剰反応を防ぐことで,免疫ホメオスタシスを維持します.

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