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Updated: May 7, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

多遺伝的イベントが共同で,Pten-null白血病の幹細胞形成に寄与する

Wei Guo1, Joseph L Lasky, Chun-Ju Chang

  • 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA.

Nature
|May 9, 2008
PubMed
まとめ

マウスの幹細胞におけるPten欠損は,β-cateninとc-myc.cを活性化することによってT-ALLを引き起こす. この研究は,白血病幹細胞の変異における重要な分子イベントを特定しています.

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Evaluation of Abnormal Growth-related Genes of Hematopoietic Stem and Progenitor Cells by Combining CRISPR/Cas9 Technology with Cell Counting07:01

Evaluation of Abnormal Growth-related Genes of Hematopoietic Stem and Progenitor Cells by Combining CRISPR/Cas9 Technology with Cell Counting

Published on: May 2, 2025

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