吸入麻酔薬のステレオ化学:ハロタン,エンフルラン,イソフルランの光学解像度

J Meinwald¹, W R Thompson, D L Pearson

¹Department of Chemistry, Cornell University, Ithaca, NY 14853-1301.

Science (New York, N.Y.)

|February 1, 1991

まとめ

研究者は,ハロタン,エンフルラン,イソフルランなどの一般的な吸入麻酔薬のエナティオメールを分離する方法を開発しました. これにより,これまで説明されていない純粋な麻酔剤の分析が可能になります.

科学分野:

アナリティカル・ケミストリー (Analytical Chemistry) とは
薬理学薬理学とは
有機化学オーガニック・ケミストリー

背景:

ハロタン,エンフルラン,イソフルランは,重要な吸入麻酔剤です.
これらの麻酔薬は現在,ラセミック混合物として投与されています.
純粋なエナンティオマーとその解消の方法は,以前は記述されていませんでした.

研究の目的:

ハロタン,エンフルラン,イソフルランの光学解像度のための分析方法の開発.
広く使用されているこれらの麻酔剤のエナティオメリック比率の決定を可能にするために.

主な方法:

キラル毛細血管ガスクロマトグラフィを用いた.
ハロタンとイソフルランの解像度のために使用されたper-n-pentylated alpha-cyclodextrin (Lipodex A).
エンフルランとイソフルランの解像度のために使用されたオクタキス ((6-O-メチル-2,3-ディ-O-ペンチル) -ガンマ-サイクロデクストリン.

主要な成果:

ラセミカルハロタン,エンフルラン,イソフルランの完全な光学解像度を達成しました.
エナティオメア比率を迅速かつ便利に決定する能力を実証した.
麻酔剤のエナティオメアを分離するための効果的なキラル静止相を確立した.

結論:

重要な吸入麻酔剤のエナティオメリック分離のための新しい分析方法が確立されました.
この方法により,これまで入手不可能だった純粋なエナチオメアの特徴づけが容易になります.
開発された技術は,麻酔用サンプルにおけるエナティオメリック比率の正確な決定を可能にします.

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