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Updated: Jul 5, 2026

Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations
05:57

Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations

Published on: April 26, 2024

ハンマーヘッドリボ酵素触媒におけるC3およびG8位置での変異効果の起源は,分子動力学シミュレーションから得られたものである

Tai-Sung Lee1, Darrin M York

  • 1Consortium for Bioinformatics and Computational Biology, and Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.

Journal of the American Chemical Society
|May 16, 2008
PubMed
まとめ

分子ダイナミクスシミュレーションにより,ハンマーヘッドリボ酵素機構が明らかになりました. G8:2'OHグループは,一般的な酸触媒として作用し,G8とC3.3の間のワトソン・クリックの水素結合によって安定させます.

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