インターフェイスインスタビリティを通じて複数の形態を持つアンフィフィリックブロックコポリマーミセルの自発的な生成
1Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Journal of the American Chemical Society
|May 16, 2008
まとめ
私たちは,エムルション滴の不安定性を用いてブロックコポリマーミセルを作成する新しい方法を開発しました. この技術により,調節可能なミセルの形状と,ナノ粒子を含む,水害性物質の組み込みが可能になります.
科学分野:
- ポリマー化学のポリマー化学について
- マテリアルサイエンス 材料科学
- ナノテクノロジー ナノテクノロジー
背景:
- ブロックコポリマーは,様々なナノ構造に自己組み立てます.
- ミセルの形状とペイロードの組み込みを制御することは,アプリケーションにとって非常に重要です.
研究 の 目的:
- ブロックコポリマーミセル形成のための新しい方法を導入する.
- ミセルの形状と貨物の負荷のチューナビリティを証明するために.
主な方法:
- 水中のアンフィフィリックブロックコポリマー (ポリステリンブロックポリエチレン酸化物) の乳化.
- 溶媒の蒸発により,界面の不安定性とミセルの形成が生じます.
- 乳化過程で水嫌性物種 (ホモポリマー,ナノ粒子) の組み込み.
主要な成果:
- 球形および円筒形のブロックコポリマーミセルの自発的形成.
- 方法:様々な水嫌性ブロック (ポリブタジーン,ポリキャプロラクトン,ポリメチルメタクリlate) で実証された方法.
- ホモポリマーまたは異なるコポリマーを加えることで得られた調節可能なミセル直径と形状.
- 鉄酸化物ナノ粒子を組み込むことで作られた磁気負荷のミセル.
結論:
- 乳液滴の界面不安定性は,コポリマーミセルをブロックする簡単な経路を提供します.
- この方法は,異なるポリマー組成物に対して多用途であり,水害性のペイロードを組み込むことを可能にします.
- このアプローチにより,薬剤投与およびナノテクノロジーにおける潜在的なアプリケーションのための機能化されたミセルの作成が可能になります.
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