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Updated: Jul 5, 2026

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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TNF-αは,2つの異なるカスパース-8活性化経路を誘導する

Lai Wang1, Fenghe Du, Xiaodong Wang

  • 1Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

Cell
|May 20, 2008
PubMed
まとめ

腫瘍死滅因子アルファ (TNF-alpha) は,2つの異なる経路を通じてアポトーシスを引き起こす. これらの経路は,サイクロヘキシミドまたはSmacミメティックを含み,cIAP1/2およびc-FLIP経由でカスパース-8の活性化を差異的に調節します.

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