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Updated: Jun 25, 2026

Assays for the Degradation of Misfolded Proteins in Cells
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ポリグルタミンプレアミロイドオリゴマーの心筋筋細胞発現は,心不全を引き起こす

J Scott Pattison1, Atsushi Sanbe, Alina Maloyan

  • 1Department of Pediatrics, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Circulation
|May 21, 2008
PubMed
まとめ

心臓細胞内で発現する溶性プレアミロイドオリゴーマー (PAO) は,マウスにおいて毒性と心不全を引き起こす. この研究は,PAOが心臓機能不全と細胞死を引き起こすのに十分であることを確認し,その病原性の役割を強調しています.

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